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丹參酮IIA

分析標(biāo)準(zhǔn)品,HPLC≥98%

Tanshinone IIA

CAS號(hào)：568-72-9

分子式：C19H18O3

分子量：294.34

MDL：MFCD00238692

產(chǎn)品介紹

熔點(diǎn)：205-207℃

沸點(diǎn)：480.7℃ at 760 mmHg

外觀：桔紅色針狀結(jié)晶

溶解性：按照順序添加:5%  DMSO+30%  PEG  300+2%  Tween  80+ddH2O。此方法可以溶解0.2mg/ml。丹參酮IIA溶液狀態(tài)下不穩(wěn)定，需要現(xiàn)配現(xiàn)用，不能儲(chǔ)備液形式儲(chǔ)存。

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(106篇)

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91. [IF=4.7] Jinpeng Sun et al."Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway."Drug Design Development and Therapy.

90. [IF=3.5] Yuanjie Wu et al."Tanshinone IIA Combined With Rutin and Squalene Improves Hyperlipidemia to Alleviate Atherosclerosis in New Zealand Rabbits Through Upregulation of the SREBP2/LDLR Pathway."JOURNAL OF FOOD BIOCHEMISTRY.2025 Apr;2025(1):8349248

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86. [IF=4.9] Zhongda Cao et al."Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Jan;25(18):9930

85. [IF=4.8] Zhengchao Ji et al."Holistic quality assessment and monitoring of YiXinShu capsule based on three-dimensional fingerprints combined with quantitative analysis, antioxidant activity and chemometrics."JOURNAL OF ETHNOPHARMACOLOGY.2024 Dec;335:118630

84. [IF=13.3] Zhicheng Xiao et al."A novel nitric oxide-driven nanomotor for synergistic treatment of ischaemic stroke: Enhanced deep brain penetration and therapeutic efficacy."CHEMICAL ENGINEERING JOURNAL.2024 Sep;496:154205

83. [IF=2.8] Fang Liang et al."Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer’s disease rat models."JOURNAL OF PHARMACY AND PHARMACOLOGY.2024 Jun;:

82. [IF=6.2] Ying Ren et al."Effect of CeO2, TiO2 and SiO2 nanoparticles on the growth and quality of model medicinal plant Salvia miltiorrhiza by acting on soil microenvironment."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Jul;280:116552

81. [IF=2.6] Cheng Shao et al."Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice."Journal of Orthopaedic Surgery and Research".2024 Dec;19(1):1-12

80. [IF=2.6] Fan Yang et al."Preliminary Exploration of Potential Active Ingredients and Molecular Mechanisms of Yanggan Yishui Granules for Treating Hypertensive Nephropathy Using UPLC-Q-TOF/MS Coupled with Network Pharmacology and Molecular Docking Strategy."Journal

79. [IF=7.9] Mingyu Wu et al."Tanshinone IIA positively regulates the Keap1-Nrf2 system to alleviate pulmonary fibrosis via the sestrin2-sqstm1 signaling axis-mediated autophagy."PHYTOMEDICINE".2024 Apr;:155620

78. [IF=10.2] Guo Hong et al."Homologous-magnetic dual-targeted metal-organic framework to improve the Anti-hepatocellular carcinoma efficacy of PD-1 inhibitor."JOURNAL OF NANOBIOTECHNOLOGY".2024 Dec;22(1):1-20

77. [IF=1.8] Meile Ma et al."Tanshinone IIA Regulates Synaptic Plasticity in Mg2+-Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway."Journal of Integrative Neuroscience".2024 Mar;23(3):61

76. [IF=9.8] Ying Ren et al."Response of antioxidant activity, active constituent and rhizosphere microorganisms of Salvia miltiorrhiza to combined application of microbial inoculant, microalgae and biochar under Cu stress."SCIENCE OF THE TOTAL ENVIRONMENT".2024 May;9

75. [IF=1.1] Ji-Yong FU et al."Simultaneous determination of 19 constituents in the Jian-Nao-Ning mixture using high-performance liquid chromatography-tandem mass spectrometry."Separation Science Plus".2024 Feb;:2300222

74. [IF=6] Honglin Liu et al."Tanshinone IIA as a therapy for PCOS via FOS/JUN/TP53 axis: Evidence from network pharmacology of Bajitian-Danshen pair."Arabian Journal of Chemistry".2024 Feb;:105641

73. [IF=10.7] Baixi Shan et al."Tanshinone IIA alleviates pulmonary fibrosis by modulating glutamine metabolic reprogramming based on [U-13C5]-glutamine metabolic flux analysis."Journal of Advanced Research".2024 May;:

72. [IF=4.7] Xu Zhang et al."Rhein: A potent immunomodulator empowering largemouth bass against MSRV infection."FISH & SHELLFISH IMMUNOLOGY.2024 Jan;144:109284

71. [IF=7.5] Xiangke Ma et al."Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2."BIOMEDICINE & PHARMACOTHERAPY.10.1016/j.biopha.2023.115501

70. [IF=8.8] Baixi Shan et al."Tanshinone II ameliorates energy metabolism dysfunction of pulmonary fibrosis using 13C metabolic flux analysis."Journal of Pharmaceutical Analysis.10.1016/j.jpha.2023.09.008

69. [IF=5] Ning Liu et al."Sulfonated azocalix[4]arene-Tanshinone IIA supramolecular drug delivery system based on hypoxic reduction response for treatment of ischemic heart disease: Enhance the solubility, stability and bioavailability of drugs."JOURNAL OF DRUG DEL

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65. [IF=5.7] Pan Shuangjia et al."Tanshinone IIA changed the amniotic fluid volume and regulated expression of AQP1 and AQP3 in amniotic epithelium cells: a promising drug treating abnormal amniotic fluid volume."MOLECULAR MEDICINE.2023 Dec;29(1):1-14

64. [IF=5.195] Jingwen Xu et al."Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis."JOURNAL OF ETHNOPHARMACOLOGY.2023 May;:116675

63. [IF=3.97] Xin Zhang et al."Nano-encapsulated tanshinone IIA in PLGA-PEG-COOH inhibits apoptosis and inflammation in cerebral ischemia/reperfusion injury."Green Processing and Synthesis.2023 Jan;12(1):

62. [IF=6.449] Chaogeng Lyu et al."A field trials-based study reveals the effects of chlormequat chloride on the quality of medicinal plant Salvia miltiorrhiza Bge. (Lamiaceae) in practical cultivation."INDUSTRIAL CROPS AND PRODUCTS.2023 Apr;194:116396

61. [IF=0] Yanshan Zhan et al."Preparation of tanshinone IIA self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts."Chinese Herbal Medicines.2023 Jan;:

60. [IF=6.208] Huan Zhao et al."Dihydrotanshinone I Inhibits the Lung Metastasis of Breast Cancer by Suppressing Neutrophil Extracellular Traps Formation."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(23):15180

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57. [IF=6.388] Yong-li Jiang et al."Tanshinone IIA improves contextual fear- and anxiety-like behaviors in mice via the CREB/BDNF/TrkB signaling pathway."PHYTOTHERAPY RESEARCH

56. [IF=4.051] Shao Hailing et al."Tanshinone IIA increased amniotic fluid volume through down-regulating placental AQPs expression via inhibiting the activity of GSK-3β."CELL AND TISSUE RESEARCH.2022 Jun;:1-12

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52. [IF=4.432] Xiaoqian Peng et al."Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice."Eur J Pharmacol. 2022 Mar;918:174772

51. [IF=2.629] Zhu Yinxing et al.PEI-PEG-Coated Mesoporous Silica Nanoparticles Enhance the Antitumor Activity of Tanshinone IIA and Serve as a Gene Transfer Vector.Evid-Based Compl Alt. 2021;2021:6756763

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45. [IF=3.434] Du Xiaoxun et al."Tanshinone IIA and Astragaloside IV Inhibit miR-223/JAK2/STAT1 Signalling Pathway to Alleviate Lipopolysaccharide-Induced Damage in Nucleus Pulposus Cells."Dis Markers. 2021;2021:6554480

44. [IF=3.682] Xiao-Wei Zhang et al."Lipophilic Extract and Tanshinone IIA Derived from Salvia miltiorrhiza Attenuate Uric Acid Nephropathy through Suppressing Oxidative Stress-Activated MAPK Pathways."Am J Chinese Med. 2020 Sep;48(06):1455-1473

43. [IF=3.69] Ke-Yu Peng et al."Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR signaling pathway in mice."J Ethnopharmacol. 2021 Jan;264:113052

42. [IF=3.69] Miao-Juan Shi et al."A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis."J Ethnopharmacol. 2020 May;253:112689

41. [IF=3.69] Qian Zhang et al."Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia."J Ethnopharmacol. 2020 Apr;252:112573

40. [IF=3.881] Yingying He et al."Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice."Neurochem Int. 2020 Feb;133:104610

39. [IF=4.411] Yuanyuan Li et al."Quantitative Determination and Validation of Four Ketones in Salvia miltiorrhiza Bunge Using Quantitative Proton Nuclear Magnetic Resonance Spectroscopy."Molecules. 2020 Jan;25(9):2043

38. [IF=5.793] Ding  Bo et al."Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro."J Neuroinflamm. 2020 Dec;17(1):1-17

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33. [IF=1.863] Ligang Jie et al."Tanshinone IIA induces apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis via blockade of the cell cycle in the G2/M phase and a mitochondrial pathway."Biological & Pharmaceutical Bulletin. 2014 Jun 11

32. [IF=7.514] Tiehua Zhang et al."In vitro and in silico perspectives on estrogenicity of tanshinones from Salvia miltiorrhiza."Food Chem. 2019 Jan;270:281

31.  Miao-Juan Shi, Xiu-Li Yan, Ben-Sheng Dong, Wen-Na Yang, Shi-Bing Su, Hui Zhang,

A network pharmacology approach to investigating the mechanism of Tanshinone IIA for the treatment of liver fibrosis,

Journal of Ethnopharmacology,

Volume 253,

2020,

112689,

IS

30.  Li, Zhe, et al. "Folic acid modified lipid-bilayer coated mesoporous silica nanoparticles co-loading paclitaxel and tanshinone IIA for the treatment of acute promyelocytic leukemia." International Journal of Pharmaceutics 586 (2020): 119576.https:##doi.org

29.  Lu?btow, Michael M., et al. "Like dissolves like? A comprehensive evaluation of partial solubility parameters to predict polymer–drug compatibility in ultrahigh drug-loaded polymer micelles." Biomacromolecules 20.8 (2019): 3041-3056.https:##doi.org/10.1021

28.  Yang, Runyu, et al. "Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1." Phytomedicine 69 (2020): 153211.https:##doi.org/10.1016/j.phymed.2020

27.  Ding, B., Lin, C., Liu, Q. et al. Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro. J Neuroinflammation 17, 302 (2020). https:##doi.org/10.1186/s12974-020-01981-4

26.  Li, Zhe, et al. "Biotinylated-lipid bilayer coated mesoporous silica nanoparticles for improving the bioavailability and anti-leukaemia activity of Tanshinone IIA." Artificial cells, nanomedicine, and biotechnology 46.sup1 (2018): 578-587.https:##doi.org/1

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